Development and Characterization of Selective FAK Inhibitors and PROTACs with <i>In Vivo</i> Activity

PROteolysis-TArgeting Chimeras (PROTACs) are a class of molecules that eliminate proteins through the cell's degradation machinery. Here, to degrade an attractive cancer drug target known as focal adhesion kinase (FAK), Nabet and Jiang labs developed novel FAK PROTAC (BSJ-04-146). They show BSJ-04-146 triggers rapid specific in cells mouse models, induces improved biological responses compared small molecule inhibitors. The cover picture depicts firefly (BSJ-04-146) luring moth (FAK) carnivorous plant (proteasome) was designed by DrawImpacts. More information can be found Research Article B. Jiang, et al.